Human Granulocyte Colony Stimulating Factor (G-CSF)
Granulocyte Colony-Stimulating Factor, or G-CSF, is a growth factor that is considered the most potent inducer of terminal differentiation to granulocytes and macrophages of leukemic myeloid cell lines. The synthesis of G-CSF can be induced by bacterial endotoxins, TNF, IL-1 and GM-CSF. Prostaglandin E2 inhibits the synthesis of G-CSF, while in epithelial, endothelial, and fibroblastic cells secretion of G-CSF is induced by IL-17. Human and mouse G-CSF are cross-reactive.Recombinant human G-CSF is a non-glycosylated protein, containing 175 amino acids and having a molecular mass of 18.8 kDa.
Ships ambient. Store frozen at -20 to -10C.
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