Mouse Interleukin-17A (IL-17A)
Interleukin-17A (IL-17A), also known as CTLA-8, is a pro-inflammatory cytokine member of a six-species family of proteins (IL-17A-17F). IL-17A is secreted mainly by activated CD4+ and CD8+ T lymphocytes and acts through its receptor, IL-17R, to induce the expression of many mediators of inflammation, most importantly, those that are involved in the proliferation, maturation and chemotaxis of neutrophils. Elevated levels of IL-17A have been associated with several conditions, including rheumatoid arthritis, airway inflammation, allograft rejection, inflammatory boweldisease, psoriasis, cancer and multiple sclerosis. Human, mouse and rat IL-17A show activity on mouse cells. Recombinant mouse IL-17A is a non-glycosylated, disulfide-linked homodimer, containing two 134 amino acid subunits and having a total molecular mass of 30 kDa.
Ships ambient. Store frozen at -20 to -10C.
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